Company intelligence / Profile preview

TopiVert Pharma Limited

London, England, United Kingdomuk.linkedin.com ↗
Ownership
Private
Development stage
Phase 2
01

Overview

TopiVert developed locally acting small molecule kinase inhibitors for chronic inflammatory diseases of the GI tract and eye. Lead program TOP1288 showed strong safety and pharmacodynamic data in a Phase I study for ulcerative colitis. Ophthalmology candidate TOP1630 demonstrated proof-of-concept efficacy in dry eye syndrome with positive results from a US-based Phase I/IIa trial. A multicenter randomized placebo-controlled phase IIb/III trial was underway for DED as of the last reports. The company’s NSKI technology aimed to provide potent anti-inflammatory effects with minimal systemic exposure.

Therapeutic areas
GastroenterologyOphthalmology
Modalities
Small molecules (specifically Narrow Spectrum Kinase Inhibitors, NSKIs)
Industry
Biotech
02

Drug pipeline

3 assets

TOP1630

3

2 more assets in the full pipeline.

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03

Partnerships

No major pharma partnerships disclosed; investors include Johnson & Johnson Innovation – JJDC, Inc., SV Health Investors, Touchstone Innovations, NeoMed.

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