Totem Probiotic

Totem is a biotechnology company focused on the human microbiome to develop a new class of live biotherapeutic products (LBPs). The company identifies and utilizes Totem microbes—bacterial species that are highly conserved, prevalent, and dominant across diverse human populations. By focusing on these foundational members of the gut ecosystem, Totem aims to overcome the challenges of colonization and variability that have hindered previous microbiome-based therapies. The company's platform is designed to treat a range of inflammatory and autoimmune diseases by restoring healthy microbial function. Totem is currently in the pre-clinical stage, advancing a pipeline of candidates derived from its proprietary discovery engine.