Trans Chromosomics

Trans Chromosomics is a Japanese biotechnology company and a spin-off from Tottori University that specializes in advanced chromosome engineering. The company leverages its proprietary Human Artificial Chromosome (HAC) and Mouse Artificial Chromosome (MAC) platforms to develop sophisticated drug discovery tools and therapeutic candidates. Its core offerings include the TC-mAb mouse, a fully humanized antibody-producing model, and the TC-huMDR1 mouse for evaluating the blood-brain barrier penetration of central nervous system drugs. Trans Chromosomics collaborates extensively with major pharmaceutical companies like Daiichi Sankyo and Eisai to accelerate the discovery of monoclonal antibodies and gene therapies for intractable conditions such as Duchenne muscular dystrophy. Additionally, the company provides specialized contract research services including high-precision karyotype and FISH analysis for regenerative medicine applications.