SHD865
Pre-clinical- Indications
- Obesity, Type 2 diabetes, Nonalcoholic fatty liver disease
Company intelligence / Profile preview
Uncoupler Biosciences
Sydney, New South Wales?, Australiapmc.ncbi.nlm.nih.gov ↗
- Ownership
- Private
- Development stage
- Preclinical
01
Overview
Uncoupler Biosciences is developing highly specific, self-limiting mitochondrial uncouplers as oral small molecule therapeutics. Their lead compound BAM15 has shown efficacy in preclinical models by reducing fat mass without affecting lean mass or food intake and improving insulin sensitivity. The company’s approach aims to treat obesity, NASH, diabetes, and potentially other age-related metabolic disorders by increasing energy expenditure at the cellular level with a favorable safety profile compared to earlier-generation uncouplers.
- Therapeutic areas
- GastroenterologyEndocrinologyMetabolic DisordersOther
- Modalities
- Small molecules (specifically mitochondrial uncouplers)
- Industry
- Biotech
02
Drug pipeline
1 assetBeyond the preview
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