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UNION Therapeutics develops novel treatments within immunology. Its lead candidate, orismilast—a next-generation PDE4 inhibitor—has shown promising efficacy and safety across multiple inflammatory skin diseases. The current focus has shifted toward hidradenitis suppurativa due to strong mechanistic fit and clinical results indicating efficacy at least comparable with biologic therapies along with unique pain reduction benefits. Orismilast may also address metabolic syndrome comorbidities common in these patients.
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