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Unnatural 20 Studios

Santa Cruz, California, United Stateslinkedin.com ↗

Ownership: Private
Development stage: Preclinical

Overview

Unnatural Products has developed an AI-driven platform that rapidly designs and optimizes orally bioavailable macrocyclic peptides targeting previously undruggable intracellular proteins. The company has demonstrated the ability to generate potent, selective compounds with improved cell permeability and oral bioavailability. Its technology has attracted partnerships with major biopharma companies like BridgeBio Pharma, which has licensed candidates for rare disease and oncology indications. No clinical results have been published yet; programs are in preclinical or earlier stages.

Therapeutic areas: ImmunologyOncologyRare Diseases
Modalities: Macrocyclic peptidePeptideSmall molecule
Industry: Biotech

Partnerships

BridgeBio Pharma (option/license agreement on macrocyclic peptides for rare disease/oncology)OpenFold AI Research Consortium member alongside Bristol Myers Squibb, Novo Nordisk, etc.Merck Global Health Innovation Fund as investor/board representation

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