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ValenzaBio is a clinical-stage biotechnology company focused on developing monoclonal antibodies for the treatment of autoimmune and inflammatory diseases. The company's lead program, VB-421, is a potent IGF-1R antagonist designed to treat Thyroid Eye Disease (TED) with a potentially improved safety and efficacy profile compared to existing therapies. Another key asset, VB-119, targets c-KIT for the treatment of Chronic Spontaneous Urticaria (CSU) and other mast cell-mediated disorders. ValenzaBio was acquired by Acelyrin in early 2023, significantly expanding Acelyrin's immunology pipeline with multiple clinical and pre-clinical programs.
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