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Variational AI
Vancouver, British Columbia, Canadavariational.ai ↗
- Ownership
- Private
- Employees
- ~14
- Development stage
- Preclinical
01
Overview
Variational AI has developed Enki™, a generative AI foundation model for small molecule drug discovery. The platform enables rapid generation of novel lead compounds with high potency and selectivity across hundreds of biological targets. In collaborations with biopharma partners such as ImmVue Therapeutics and Rakovina Therapeutics, the company has delivered experimentally validated preclinical leads—achieving a sub-micromolar hit rate over 50% and synthetic success rate of about 90%. No clinical-stage assets are currently disclosed; all programs are at the preclinical/lead optimization stage.
- Therapeutic areas
- OncologyOther
- Modalities
- small molecules
- Industry
- Drug Discovery Services
02
Partnerships
ImmVue Therapeutics (immuno-oncology lead generation)Rakovina Therapeutics (DDR kinase inhibitors for cancer)Merck & Co. was an early user of the Enki™ platform in early-stage drug discovery projects
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