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Vaxeal has developed long synthetic peptide vaccines targeting Survivin, Cyclin B1, and Midkine, combined with immune checkpoint inhibitors. Pre-clinical validation has demonstrated efficacy and lack of toxicity across several animal and ex vivo human models, with first-in-human studies planned. Some staff participated in unrelated Phase 1/2 trials with promising tolerability and efficacy; first clinical studies of lead products SVX-1 and CBX-1 were targeted for completion by 2020–2022.[2][5]
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