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Vical developed biopharmaceutical products using its proprietary DNA delivery platform. Its most advanced program was Allovectin-7®, an immunotherapeutic for metastatic melanoma that reached a pivotal Phase 3 trial. Another key program was a cytomegalovirus DNA vaccine in Phase 2 trials for stem cell transplant recipients. The company also explored vaccines for pandemic influenza and other infectious diseases. Clinical results were mixed; Allovectin failed to meet endpoints in its pivotal trial.
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