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Vincentage's lead program, VCT220 (now CX11 outside China), is an oral small molecule GLP-1 receptor agonist for obesity and overweight. Phase 2 trials in China showed robust, dose-dependent weight loss of up to 9.7% at highest dose and a favorable safety/tolerability profile, with no serious drug-related adverse events. A Phase 3 registrational trial is underway in China as of late 2024, and ex-China rights have been licensed to Corxel, which has begun a Phase 2 U.S. trial. The company's program has shown efficacy similar to injectable GLP-1 drugs, with oral administration and best-in-class tolerability.[1][2][3][4][5]
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