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The iLSTA trial (Phase 1b/2a) combining certepetide (iRGD peptide) with immunotherapy (durvalumab) and chemotherapy (nab-paclitaxel, gemcitabine) for locally advanced, non-resectable pancreatic ductal adenocarcinoma demonstrated a 60% overall response rate (partial response 65%, complete response 5%), 100% disease control rate; 16/20 had decreased CA19-9, with 7 showing >90% reduction. All patients experienced either partial response, complete response, or stable disease, indicating promising early results.
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