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Wave Life Sciences has achieved the first-ever therapeutic RNA editing in humans in its RestorAATion‑2 trial of WVE‑006 for alpha‑1 antitrypsin deficiency. The company is advancing clinical and preclinical programs targeting rare and prevalent disorders using a suite of proprietary RNA-targeting modalities. Its lead programs include candidates for alpha‑1 antitrypsin deficiency, Duchenne muscular dystrophy, Huntington’s disease, and obesity
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