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Xilio Therapeutics has reported early-phase clinical results for its lead candidates, including vilastobart (masked anti-CTLA-4 + PD-L1) in combination with atezolizumab and efarindodekin alfa (masked IL-12), demonstrating tumor-selective activation with the aim to improve efficacy and minimize systemic toxicity in various advanced solid tumors and colorectal cancer. Several other programs are in preclinical and IND-enabling stages.
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