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XM Therapeutics has demonstrated proof-of-concept that its injectable ECM biologic products can alter dysfunctional extracellular matrix composition to reduce scar size and improve muscle contractility in preclinical heart models. The company remains at the pre-clinical stage with ongoing studies focused on cardiovascular and respiratory diseases such as heart failure and pulmonary fibrosis. Proteomic profiling supports their mechanistic insights into ECM modulation.[1][2][3]
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