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XORTX Therapeutics has multiple active clinical and preclinical programs. XRx-026 is at pre-NDA filing for gout, XRx-008 is in advanced clinical development for autosomal dominant polycystic kidney disease (ADPKD), XRx-101 is in clinical trials for acute kidney injury associated with COVID-19, and XRx-225 is at the preclinical stage for type 2 diabetic nephropathy. Their main mechanism is inhibition of xanthine oxidase and reduction of uric acid levels[1][2][3][6].
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