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Zhuhai Yufan Biotechnologies Co., Ltd.

Zhuhai, Guangdong, Chinapmc.ncbi.nlm.nih.gov ↗

Ownership: Private
Development stage: Phase 1

Overview

Zhuhai Yufan Biotechnologies is a subsidiary of Yinming Biotech focused on the discovery and development of novel small molecule therapeutics for oncology. Its lead asset is PRJ1‑3024—an oral HPK1 inhibitor currently in Phase I/II clinical trials for advanced solid tumors. The company also develops next-generation CAR-T therapies with genetic deletion of HPK1 to overcome T-cell exhaustion. Early pipeline programs target CDK4/CDK6 and Cbl-b with applications in glioma and non-small cell lung cancer. No approved products as of May 2025.[5][8][9]

Therapeutic areas: OncologyImmunology
Modalities: Small moleculesCell therapy (CAR-T, HPK1 gene deletion)[5]PROTACs[4]
Industry: Biotech

Drug pipeline

1 asset

prj1-3024

Partnerships

Abound Bio – multi-year agreement to develop next-generation CAR-T therapies using Abound’s antibodies combined with enhanced HPK-inhibited CAR T-cells targeting up to ten novel cancer antigens.[5]

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