α-NAPAP

α-NAPAP (alpha-NAPAP) is a highly potent, selective, and competitive small-molecule direct thrombin inhibitor. It reversibly binds to the active site of thrombin, mimicking the basic amino acid residues (arginine and lysine) typically cleaved by trypsin-like serine proteases. In preclinical research, α-NAPAP is widely utilized as an anticoagulant and neuroprotective agent. It has been shown to significantly reduce brain edema, blood-brain barrier breakdown, and seizure activity in animal models of status epilepticus, traumatic brain injury, and intracerebral hemorrhage by blocking thrombin-mediated activation of protease-activated receptor 1 (PAR1).

Brand names

Pefabloc TH

Other names

alpha-NAPAPN-alpha-(2-naphthalenesulfonylglycyl)-4-amidino-D,L-phenylalaninepiperidideN-alpha-(2-naphthalenesulfonylglycyl)-4-amidino-DL-phenylalaninepiperidideNAPAPNα-(2-naphthalenesulfonylglycyl)-4-amidino-D,L-phenylalaninepiperidideNα-(2-naphthalenesulfonylglycyl)-4-amidino-DL-phenylalaninepiperidideThrombstopThromstop