α-SC6

α-SC6 is an investigational structure-based vaccine antigen rationally designed to target misfolded conformers of **alpha-synuclein**, which are implicated in the pathogenesis of Parkinson’s disease, dementia with Lewy bodies, multiple system atrophy, and related synucleinopathies. Its design involves engineering the surface residues of a scaffold protein to mimic structural regions of alpha-synuclein fibrils, with the goal of eliciting a specific immune response against pathological forms of alpha-synuclein, thus aiming to provide prophylactic and potentially therapeutic benefit in synuclein-associated diseases[5].