β-catenin siRNA

β-catenin siRNA is a therapeutic modality utilizing small interfering RNA to silence the expression of the CTNNB1 gene, which encodes the β-catenin protein. β-catenin is a central component of the canonical Wnt signaling pathway and plays a critical role in cell-cell adhesion and gene transcription. Dysregulation of β-catenin, often through gain-of-function mutations or overexpression, is a driver in various malignancies, including acute megakaryoblastic leukemia (AMKL) and head and neck squamous cell carcinoma. By targeting the mRNA of β-catenin for degradation via the RNA-induced silencing complex (RISC), siRNA can reduce protein levels, leading to inhibited cell proliferation, increased apoptosis, and enhanced sensitivity to radiotherapy. Current research focuses on advanced delivery systems, such as cancer cell membrane-coated PLGA nanoparticles, to overcome the challenges of systemic delivery and achieve tumor-specific targeting.

Other names

CTNNB1 siRNACTNNB-1 siRNACTNNB 1 siRNAbeta-catenin siRNA