Drug intelligence / Profile preview

β-conglycinin

Development stage
Preclinical
Lead developer
Pfizer
Modality
Recombinant Proteins and Enzymes
Administration
Oral
01

Overview

β-conglycinin is a **soy-derived storage protein fraction** found in soybeans and soy protein isolate, generally regarded as a functional food ingredient rather than a conventional pharmaceutical drug. In human studies, orally administered β-conglycinin has been investigated as a nutraceutical ingredient for **hypertriglyceridemia, visceral adiposity, obesity, and broader lifestyle-related metabolic disorders**. Its proposed mechanism is not a single receptor-ligand pharmacology; instead, it appears to act as a **dietary protein/nutraceutical** that can improve lipid metabolism and reduce serum triglycerides and visceral fat, likely through metabolic and hepatic lipid-handling effects associated with soy protein consumption. The provided randomized placebo-controlled study used β-conglycinin-containing candy and reported reductions in serum triglycerides and visceral fat versus casein control.

Other names
β-conglycininbeta-conglycininsoybean beta-conglycininsoy beta-conglycinin7S globulin
02

Targets

FPR1 (Formyl peptide receptor 1)

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