βIII-tubulin siRNA

βIII-tubulin siRNA is a small interfering RNA (siRNA) research reagent designed to silence the expression of the TUBB3 gene, which encodes the Class III β-tubulin protein. This protein is a microtubule component often aberrantly expressed in various aggressive cancers, including glioblastoma, non-small cell lung cancer (NSCLC), and pancreatic cancer, where it is associated with increased tumor grade and resistance to chemotherapy. By utilizing the RNA interference (RNAi) pathway to degrade TUBB3 mRNA, this siRNA knocks down βIII-tubulin levels, thereby sensitizing tumor cells to tubulin-binding agents (such as paclitaxel and vincristine) and DNA-damaging agents (such as temozolomide and cisplatin). Preclinical studies have demonstrated that silencing βIII-tubulin can lead to increased apoptosis, induced senescence, and reduced tumor cell colony formation and neurosphere growth.

Other names

TUBB3 siRNATUBB-3 siRNATUBB 3 siRNAClass III beta-tubulin siRNAbeta-III tubulin siRNA