Drug intelligence / Profile preview

⁶⁸Ga-NOTA-LSA

Development stage: Preclinical
Lead developer: Seoul National University
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes
Administration: Intravenous

Overview

⁶⁸Ga-NOTA-LSA (also known as [68Ga]Ga-NOTA-LSA) is a gallium-68-labeled, lactosylated human serum albumin (LSA) conjugate coupled with the chelator NOTA (2-(p-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid). It is designed as a positron emission tomography (PET) radiopharmaceutical targeting the asialoglycoprotein receptor (ASGPR, specifically ASGR1) on hepatocytes. By binding to ASGPR, the tracer allows for the quantitative, non-invasive assessment of functional hepatic reserve (FHR) and future remnant liver function, which is critical for preoperative planning in patients undergoing hepatectomy or evaluating liver fibrosis. The agent has been formulated as a sterile, lyophilized kit to enable rapid, one-step radiolabeling with high efficiency and stability.

Other names: 68Ga-NOTA-LSA68Ga-NOTA-lactosylated human serum albuminGa-68-NOTA-LSAGa68-NOTA-LSAGa 68-NOTA-LSA[68Ga]Ga-NOTA-LSAgallium-68 NOTA-lactosylated human serum albumingallium68 NOTA-lactosylated human serum albumingallium 68 NOTA-lactosylated human serum albumin

Targets

ASGPR (Asialoglycoprotein Receptor 1)

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