Drug intelligence / Profile preview

氨酚麻美干混悬剂

Development stage
Unknown
Lead developer
Zhejiang Kangde Pharmaceutical Group
Modality
Small Molecules
Administration
Oral
01

Overview

氨酚麻美干混悬剂 (Anfenmamei Ganhunxuanji) is a combination small molecule drug product developed and manufactured by Zhejiang Kangde Pharmaceutical for the symptomatic relief of the common cold and influenza in children. Formulated as a dry suspension for oral reconstitution, it contains three active pharmaceutical ingredients: paracetamol (acetaminophen), pseudoephedrine hydrochloride, and dextromethorphan hydrobromide. Paracetamol acts as an analgesic and antipyretic by inhibiting prostaglandin synthesis in the central nervous system. Pseudoephedrine is a sympathomimetic decongestant that targets alpha- and beta-adrenergic receptors to reduce nasal congestion. Dextromethorphan serves as an antitussive by suppressing the cough reflex through sigma-1 receptor agonism and NMDA receptor antagonism. The drug is approved in China for treating symptoms such as fever, headache, nasal congestion, and cough associated with viral respiratory infections.

Other names
Anfenmamei GanhunxuanjiAn Fen Ma Mei dry suspensionParacetamol, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide Dry Suspension
02

Targets

PGHS-1 (Prostaglandin G/H Synthase 1)NMDAR (Glutamate receptor ionotropic, NMDA)ADRB1 (β1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)ADRA1A (α1A)

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