Drug intelligence / Profile preview

오티렌F정 (artemisia asiatica extract)

Development stage: Unknown
Lead developer: Daewon Pharm
Modality: Small Molecules
Administration: Oral

Overview

Otiren F (오티렌F정) is a gastric-retentive floating tablet formulation of *Artemisia asiatica* 95% ethanol extract, developed by Daewon Pharm for the treatment of gastritis. Utilizing a floating drug delivery system (FDDS), the tablet is designed to remain buoyant in the gastric juice, thereby prolonging the residence time of the active ingredient in the stomach and enhancing its local cytoprotective effects. The active extract contains flavonoids such as eupatilin and jaceosidin, which exhibit anti-inflammatory and antioxidant properties, promoting the secretion of mucus and bicarbonate while inhibiting gastric acid-induced mucosal damage. It is approved in South Korea for the improvement of gastric mucosal lesions (erosion, hemorrhage, redness, edema) associated with acute and chronic gastritis.

Brand names: Otiren F오티렌F정Otiren
Other names: Artemisia asiatica 95% ethanol extract애엽95%에탄올연조엑스eupatilinjaceosidin

Targets

FOS (Activator Protein 1)ALOX5 (Arachidonate 5-lipoxygenase)MAPK14 (p38 mitogen-activated protein kinase alpha)mTOR (Mammalian target of rapamycin kinase)NF-κBNFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)NOS2 (Nitric Oxide Synthase 2)XO (Xanthine Oxidoreductase)

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