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(2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide
- Development stage
- Preclinical
- Modality
- Small Molecules
01
Overview
(2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide is a synthetic small molecule belonging to the class of alpha amino acid amides. It has been studied as an experimental compound and is not approved for clinical use. Structural biology studies have shown that it binds to beta-secretase 1 (BACE1), a key enzyme involved in the cleavage of amyloid precursor protein, which is implicated in Alzheimer's disease pathology. The compound has been co-crystallized with human BACE1, indicating its role as a BACE1 inhibitor candidate[5][6]. No clinical trials or approved indications are reported for this molecule.
- Other names
- (2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide(2S)-4-[(4-fluorophenyl)methyl]-N-(2-sulfanylethyl)piperazine-2-carboxamide(2S)-4-((4-fluorophenyl)methyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide
02
Targets
BACE1 (Beta-site APP-cleaving enzyme 1)
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