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(3S)-N-(3-bromophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
- Development stage
- Preclinical
- Modality
- Small Molecules
01
Overview
(3S)-N-(3-bromophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide is an experimental small molecule belonging to the class of anilides. It has been identified as a potent inhibitor of InhA, the enoyl acyl carrier protein reductase from Mycobacterium tuberculosis, which is a validated antimicrobial target involved in mycobacterial fatty acid elongation. The compound was discovered through high-throughput screening and subsequent optimization for increased potency as an InhA inhibitor. Only one enantiomer exhibits inhibitory activity against InhA, suggesting stereospecific binding[2][1].
- Other names
- N-(3-bromophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
02
Targets
FabI (Enoyl-acyl carrier protein reductase FabI)
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