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(3Z)-6-(4-hydroxy-3-methoxyphenyl)-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-2H-indol-2-one
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
This compound is an experimental small molecule belonging to the class of methoxyphenols. It acts as an inhibitor of serine/threonine-protein kinase Chk1 (Checkpoint kinase 1), a key regulator in the DNA damage response pathway. By inhibiting Chk1, this molecule may interfere with cell cycle arrest and DNA repair mechanisms in cancer cells, potentially sensitizing them to DNA-damaging agents. The compound has not been approved for any indication and is primarily studied as a research tool or lead structure for anticancer drug development[1][4][9].
- Other names
- (3Z)-6-(4-hydroxy-3-methoxyphenyl)-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydroindol-2-one6-(4-hydroxy-3-methoxyphenyl)-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydroindol-2-oneCHK1_HUMAN
02
Targets
CHEK1 (Checkpoint kinase 1)
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