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(5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
This compound is a synthetic small molecule inhibitor of heat shock protein 90-alpha (HSP90α), a molecular chaperone involved in the folding and stabilization of various client proteins critical for cancer cell survival. It belongs to the class of phenylpyridines and quinazolines. The drug is experimental and has not been approved for any indication. Its primary mechanism is inhibition of HSP90α activity, which may disrupt multiple oncogenic signaling pathways dependent on this chaperone[1][2][6].
- Other names
- (NE)-N-[(7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime(NE)-N-[(7S)-2-amino-7-(4-fluoro-2-pyridin‑3‑ylphenyl)‑4‑methyl‑7,8‑dihydroquinazolin‑5‑ylidene]hydroxylamine
02
Targets
HSP90AA1 (Heat shock protein HSP90-alpha)
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