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(5s)-1-benzyl-3-(1,1-dioxido-1,2-benzisothiazol-3-yl)-4-hydroxy-5-(1-methylethyl)-1,5-dihydro-2h-pyrrol-2-one
- Development stage
- Preclinical
- Modality
- Small Molecules
01
Overview
This compound, also known as (5S)-1-Benzyl-3-(1,1-dioxido-1,2-benzothiazol-3-yl)-4-hydroxy-5-isopropyl-1,5-dihydro-2H-pyrrol-2-one, is a small molecule identified as a potent and selective inhibitor of IκB kinase β (IKKβ). IKKβ is a crucial enzyme in the classical NF-κB pathway, which plays a significant role in inflammation and cancer. Due to its IKKβ inhibitory activity, it is investigated as a potential anti-inflammatory agent.
- Other names
- (5S)-1-Benzyl-3-(1,1-dioxido-1,2-benzothiazol-3-yl)-4-hydroxy-5-isopropyl-1,5-dihydro-2H-pyrrol-2-one(S)-1-Benzyl-3-(1,1-dioxo-benzo[d]isothiazolium ylide)
02
Targets
IKBKB (IKKβ)
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