(5Z)-7-Oxozeanol

(5Z)-7-Oxozeanol (also known as 5Z-7-oxozeaenol) is a naturally occurring resorcylic acid lactone fungal metabolite that acts as a potent, selective, and irreversible inhibitor of transforming growth factor-β-activated kinase 1 (TAK1, also known as MAP3K7). It covalently binds to a conserved cysteine residue in the ATP-binding pocket of TAK1. By blocking TAK1, (5Z)-7-Oxozeanol prevents the downstream activation of NF-κB and MAPK (p38, JNK, ERK) signaling pathways, which are critical mediators of inflammatory responses and cell survival. It is widely used as a chemical biology tool and research reagent to study inflammatory cascades, autoimmune diseases, and cancer progression, particularly in sensitizing cancer cells to chemotherapy-induced apoptosis.

Other names

(5Z)-7-Oxozeaenol5Z-7-Oxozeaenol5Z-7-OxozeanolLL Z1640-2LL-Z 1640-2LL-Z1640-2LL-Z-1640-2