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(E)-2-fluoro-p-hydroxycinnamate
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
(E)-2-Fluoro-p-hydroxycinnamate is a small molecule experimental compound that acts as a competitive inhibitor of the enzyme phenylpyruvate tautomerase, which is also known as macrophage migration inhibitory factor (MIF). MIF is an immunoregulatory cytokine with enzymatic activity involved in tautomerization reactions. Structural studies have shown that (E)-2-fluoro-p-hydroxycinnamate binds in the active site of MIF, interacting with key residues and confirming its role as an inhibitor. The compound has been used primarily for biochemical and structural studies to elucidate the mechanism of MIF/PPT catalysis and inhibition[3][7][9]. There are no approved therapeutic indications or clinical trials for this molecule.
- Other names
- 4-((1E)-2-carboxy-2-fluoroeth-1-en-1-yl)benzen-1-olate4-[(1E)-2-carboxy-2-fluoroeth-1-en-1-yl]benzen-1-olate2-fluoro-3-(4-hydroxyphenyl)-2E-propenoate(E)-2-FLUORO-P-HYDROXYCINNAMATE
02
Targets
MIF (Oxidized macrophage migration inhibitory factor)
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