(R)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-Benzamide

(R)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-Benzamide is a synthetic small molecule belonging to the benzenesulfonamide class. It was designed as a potent and selective inhibitor of human carbonic anhydrase II (CA II), an enzyme involved in the reversible hydration of carbon dioxide. The compound exhibits picomolar affinity for CA II, with the R-enantiomer showing higher potency than its S-enantiomer. Its mechanism involves binding to and inhibiting the catalytic activity of CA II, which plays roles in pH regulation and CO₂ transport. This compound has been studied primarily as a chemical probe or lead structure for drug discovery rather than as a marketed pharmaceutical agent[1][6][7].

Other names

N-[(2R)-3-(1H-indol-1-yl)-2-methylpropyl]-4-sulfamoylbenzamideBenzamide, 4-(aminosulfonyl)-N-[(2R)-3-(1H-indol-1-yl)-2-methylpropyl]-