(R,R)-penehyclidine fumarate

(R,R)-penehyclidine fumarate is a potent, long-acting anticholinergic agent and the most pharmacologically active stereoisomer of penehyclidine. Developed by the Institute of Toxicology and Pharmacology at the Academy of Military Medical Sciences in China, it functions as a selective antagonist of M1 and M3 muscarinic receptors and nicotinic receptors, while exhibiting significantly lower affinity for M2 receptors. This selectivity profile is designed to provide effective inhibition of glandular secretions and smooth muscle relaxation without the significant tachycardia often induced by non-selective anticholinergics like atropine. It is primarily utilized as a pre-anesthetic medication to inhibit secretions and as a treatment for organophosphate nerve agent poisoning.

Other names

(R,R)-penehyclidine fumaratepenehyclidine fumarate