1,2-icosapentoyl-sn-glycero-3-phosphoserine

1,2-Icosapentoyl-sn-glycero-3-phosphoserine is a synthetic phospholipid derivative containing two eicosapentaenoic acid (EPA) chains esterified to the sn-glycerol backbone and a phosphoserine head group. It is classified as a small molecule and has been included in combination prescription products such as EnBrace HR and EnLyte for oral administration. These products are marketed primarily as medical foods or dietary supplements intended to support nutritional needs in specific patient populations. The precise mechanism of action of this compound within these formulations is not fully characterized; however it may serve as a source of omega‐3 fatty acids and contribute to membrane structure or function[1][2][6]. There is no evidence that it acts via a defined pharmacological target.

Brand names

EnBrace HREnLyte

Other names

1,2-Icosapentoyl-sn-glycero-3-phosphoserineL-serine, 2,3-bis((1-oxo-5,8,11,14,17-eicosapentaenyl)oxy)propyl hydrogen phosphate (ester), (R-(all-Z))-2-amino-3-[({2-[(6Z,9Z,12Z,15Z,18Z)-henicosa-6,9,12,15,18-pentaenoyloxy]-3-[5Z,...]pentaenoyloxy]propoxy}(hydroxy)phosphoryl)oxy]propanoic acid