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1-(2-cyclopropylethyl)-3-(1,1-dioxo-2H-1,2,4-benzothiadiazin-3-yl)-6-fluoro-4-hydroxy-2(1H)-quinolinone
- Development stage
- Preclinical
- Lead developer
- GSK
- Modality
- Small Molecules
01
Overview
This compound is a synthetic small molecule belonging to the fluoroquinolone class and features a fused benzothiadiazine ring. It was discovered as part of a new class of hepatitis C virus (HCV) polymerase inhibitors through high-throughput screening by GlaxoSmithKline. The compound potently inhibits HCV RNA-dependent RNA polymerase activity and blocks replication in cellular models. It has demonstrated excellent potency in biochemical and cellular assays but has not advanced to clinical development or approval[5][2]. Its primary mechanism is antiviral activity targeting viral replication.
- Other names
- CDBFH-quinolinone2(1H)-QUINOLINONE, 1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BENZOTHIADIAZIN-3-YL)-6-FLUORO-4-HYDROXY-1-(2-cyclopropylethyl)-3-(1,1-dioxo-4H-1lambda6,2,4-benzothiadiazin-3-yl)-6-fluoro-4-hydroxyquinolin-2-one
02
Targets
NS5B (Hepatitis C virus non-structural protein 5B (NS5B) RNA-dependent RNA polymerase)
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