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Drug intelligence / Profile preview
1-19F-fluoro-deoxy-mannoheptulose
- Development stage
- Preclinical
- Lead developer
- Centrum für Angewandte Nanotechnologie
- Modality
- Small Molecules
- Administration
- Intravenous, Parenteral
01
Overview
1-19F-fluoro-deoxy-mannoheptulose (also known as 1-deoxy-1-fluoro-D-mannoheptulose or 1-19FMH) is a fluorinated seven-carbon monosaccharide derivative of D-mannoheptulose. It is developed as a non-invasive diagnostic imaging agent for 19F magnetic resonance imaging (MRI) to detect and quantify GLUT2-expressing cells, such as pancreatic beta-cells and hepatocytes. Like its parent compound D-mannoheptulose, 1-19F-fluoro-deoxy-mannoheptulose is specifically transported into cells via the GLUT2 transporter and acts as an inhibitor of glucokinase, which can transiently inhibit glucose-stimulated insulin secretion. This agent is being investigated for its potential utility in monitoring beta-cell mass in diabetes models and for the early detection of hepatic tumors.
- Other names
- 1-19FMH1-deoxy-1-fluoro-D-manno-hept-2-ulose1-deoxy-1-fluoro-D-mannoheptulose1-FMH1-fluoro-1-deoxy-D-mannoheptulose1-fluoro-deoxy-mannoheptulose
02
Targets
GCK (Glucokinase)SLC2A2 (Solute carrier family 2 facilitated glucose transporter member 2)
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