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1-acetyl-2-lyso-sn-glycero-3-phosphoethanolamine
- Development stage
- Preclinical
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Intramuscular, Intravenous, Subcutaneous, Topical
01
Overview
1-acetyl-2-lyso-sn-glycero-3-phosphoethanolamine is a synthetic derivative of phosphatidylethanolamine, a class of glycerophospholipids found in biological membranes. It can act as an inhibitor of the enzyme phospholipase A2 and also inhibits angiotensin-converting enzyme. Additionally, it has demonstrated inhibitory activity against herpes simplex virus in vitro. This compound may be used as a component in liposomal formulations for drug delivery or vaccine development, including mRNA vaccines where it serves as part of the lipid mixture forming liposomes[2][6]. Its mechanism involves modulation of membrane-associated enzymes and potential antiviral effects.
- Other names
- 1-acetyl-2-lyso-sn-glycero-3-phosphoethanolamine
02
Targets
ACE (Angiotensin Converting Enzyme)PLA2 (Phospholipase A2 group IID)
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