Drug intelligence / Profile preview

1-Androstenediol

Development stage
Unknown
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Oral
01

Overview

**1-Androstenediol** is a synthetic anabolic steroid and prohormone of 1-testosterone (Δ¹-DHT). It is structurally classified as a C19 steroid hormone and acts primarily by being converted in the body to the potent anabolic androgen 1-testosterone through enzymatic reactions involving both 17-hydroxysteroid dehydrogenases and 3-hydroxysteroid dehydrogenases. The resulting metabolite binds to androgen receptors and activates signaling pathways that promote muscle growth and other masculinizing effects. It has been used as a dietary supplement for its potential anabolic properties but is now banned by the World Anti-Doping Agency due to its relation to anabolic steroids. There are no approved medical indications or strong scientific evidence supporting its use for any condition[1][6].

Other names
5α-androst-1-ene-3β,17β-diol4,5α-dihydro-δ1-4-androstenediol1-AD
02

Targets

AR (Adrenergic receptors)

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