1-benzoyl amino-1,2,3,4-tetrahydroisoquinoline

1-benzoyl amino-1,2,3,4-tetrahydroisoquinoline is a synthetic small molecule tetrahydroisoquinoline derivative developed by researchers at Florida A&M University as a potential antineoplastic agent. It acts as a selective estrogen receptor modulator (SERM), targeting estrogen receptor alpha (ER-α) and estrogen receptor beta (ER-β). In preclinical studies, the compound demonstrated potent in vitro cytotoxicity against breast cancer cell lines (MCF-7 and MDA-MB-231) and the Ishikawa endometrial cancer cell line, showing significantly higher potency than tamoxifen.

Other names

1-benzoylamino-1,2,3,4-tetrahydroisoquinolineN-(1,2,3,4-tetrahydroisoquinolin-2-yl)benzamidecompound 6acompound6acompound-6a