1-deoxy-1-methoxycarbamido-beta-D-glucopyranose

1-deoxy-1-methoxycarbamido-beta-D-glucopyranose is a synthetic small molecule belonging to the class of hexoses, specifically a β-D-glucopyranosylamine analog. It has been studied as an experimental inhibitor of glycogen phosphorylase, particularly the muscle form (PYGM), which plays a key role in carbohydrate metabolism by catalyzing the breakdown of glycogen. Inhibition of this enzyme is being explored as a potential strategy for controlling hepatic glycogenolysis and managing hyperglycemia. The compound binds at the catalytic site of glycogen phosphorylase, forming direct and water-mediated hydrogen bonds with key residues and inducing minor conformational changes in the enzyme[1][5][7]. Its development status remains experimental.

Other names

1-Deoxy-1-Methoxycarbamido-Beta-D-GlucopyranoseN-(Methoxycarbonyl)-β-D-glucopyranosylamine