1-deoxymannojirimycin

**1-deoxymannojirimycin** is a small molecule inhibitor of class I α-mannosidase enzymes. It acts as a competitive and selective inhibitor of α-mannosidase I in the N-glycan processing pathway within the endoplasmic reticulum and Golgi apparatus. By inhibiting this enzyme's activity at nanomolar concentrations (IC50 ≈ 0.02 μM), it blocks the biosynthesis of complex-type oligosaccharides on glycoproteins and disrupts N-linked glycosylation[4][7][10]. This inhibition can induce ER stress in human cells[7]. The compound has demonstrated antiviral activity; derivatives have shown anti-HIV effects[1][2]. It is primarily used as an experimental tool in biochemical research to study glycoprotein processing and viral replication mechanisms.

Other names

D-manno-DeoxynojirimycinDeoxymannojirimycin3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3R,4R,5R)-(2R,3R,4R,5R)-2-(hydroxymethyl)piperidine-3,4,5-triol1-deoxy-mannojirimycin1-deoxynojirimycin (sometimes used interchangeably but is a related compound)LU-1LU1LU 1Antibiotic LU-11,5-Dideoxy-1,5-imino-D-mannitol