1-phenylcyclohexylamine

**1-Phenylcyclohexylamine** is a synthetic aralkylamine compound with the molecular formula C12H17N and a molecular weight of approximately 175.27 g/mol[2][6]. It is structurally related to phencyclidine (PCP), differing by the replacement of PCP’s piperidine ring with a primary amino group[5]. This compound acts as an analog and precursor in the synthesis of PCP[4]. Pharmacologically, it has been shown to possess anticonvulsant activity in animal models, particularly effective in blocking maximal electroshock seizures and antagonizing NMDA-induced behavioral effects at higher doses[5]. Its mechanism involves noncompetitive antagonism at ionotropic glutamate receptors (notably NMDA receptor-coupled channels)[5]. It is classified as an experimental and illicit substance, not approved for medical use, and is listed as a DEA Schedule II controlled substance due to its high potential for abuse and dependence[2][1].

Other names

Cyclohexanamine, 1-phenyl-1-phenylcyclohexan-1-amine2201-24-3