1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole

A synthetic small molecule belonging to the phenylpyrazole class, 1‑Phenylsulfonamide‑3‑Trifluoromethyl‑5‑Parabromophenylpyrazole (also known as SC‑558), is a potent and selective inhibitor of prostaglandin G/H synthase 2 (commonly known as cyclooxygenase‑2 or COX‑2). It is not approved for clinical use but has been widely used in research to study COX‑2 inhibition. The compound exhibits high selectivity for COX‑2 over COX‑1, with an IC50 value of approximately 9.3 nM for COX‑2 inhibition[2][3]. Its primary application is in experimental pharmacology and biochemistry as a tool compound to investigate inflammatory pathways mediated by prostaglandins.

Other names

4-(5-(4-bromophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzene-1-sulfonamide4-[5-(4-bromophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide4-[5-(4-bromophenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamidebenzenesulfonamide, 4-[5-(4-bromophenyl)-3-(trifluoromethyl)-1h-pyrazol-1-yl]-