10-DEBC

10-DEBC (10-[4′-(N,N-Diethylamino)butyl]-2-chlorophenoxazine) is a selective small molecule inhibitor of **AKT** (protein kinase B). It is widely utilized in preclinical research as **AKT Inhibitor IV**. The compound functions by preventing the translocation of AKT to the plasma membrane, a necessary step for its phosphorylation and subsequent activation. In various cancer models, including pancreatic and breast cancer, 10-DEBC has demonstrated the ability to suppress cell proliferation, migration, and invasion. It is frequently studied in combination with other targeted agents, such as the SRC inhibitor PP2 or novel apoptosis inducers like LCTA-3344, to investigate synergistic anti-tumor effects and strategies to overcome therapeutic resistance.

Other names

10-[4′-(N,N-Diethylamino)butyl]-2-chlorophenoxazine10-(4-(diethylamino)butyl)-2-chloro-10H-phenoxazine