1000 ppm fluoride toothpaste

A standard fluoride-containing toothpaste, specifically Colgate Cavity Protection, utilized as the control arm in a Phase 3 clinical trial (NCT02535312) sponsored by Tufts University. The trial evaluates changes in the oral environment of adult patients suffering from medication-induced xerostomia (dry mouth). This control formulation contains 1000 ppm fluoride (typically as sodium fluoride), which serves as the active comparator against an investigative 8% arginine-containing toothpaste. Fluoride is a well-established pharmaceutical agent for the prevention of dental caries; it works by promoting the remineralization of tooth enamel and inhibiting the metabolic activity of acid-producing oral bacteria. In the context of the Tufts study, it was used to establish a baseline for oral health parameters in patients taking multiple xerostogenic medications.

Brand names

Colgate Cavity Protection Fluoride Toothpaste

Other names

fluoride toothpaste-Tufts University-xerostomia1000 ppm F toothpasteSodium fluoride toothpaste