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101-PGC-005 + standard of care
- Development stage
- Preclinical
- Lead developer
- PIF Partners
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
101-PGC-005 is a Type IA prodrug of dexamethasone designed to selectively target CD206+ (mannose receptor-positive) activated macrophages. This targeted delivery aims to enhance the anti-inflammatory efficacy of dexamethasone while minimizing systemic side effects, particularly suppression of the hypothalamic-pituitary-adrenal (HPA) axis. The drug is being developed for use in combination with standard of care therapies for hospitalized patients with moderate COVID-19 and has also received FDA Rare Pediatric Disease Designation for systemic juvenile idiopathic arthritis (sJIA) flares. In clinical trials, 101-PGC-005 is administered as a bolus injection and compared against conventional dexamethasone therapy, with all patients receiving additional standard treatments as appropriate[1][2][3][4][5].
- Other names
- 005 + standard of care
02
Targets
GR (Glucocorticoid receptor)MRC1 (Mannose Receptor C-type 1)
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