10C7

10C7 is an experimental antibody-drug conjugate (ADC) consisting of a monoclonal antibody (clone 10C7) targeting the Adhesion G protein-coupled receptor G1 (GPR56/ADGRG1), conjugated to a duocarmycin payload. GPR56 is highly expressed in colorectal cancer (CRC), particularly in the microsatellite stable (MSS) subtype, and its expression is associated with poor survival and treatment resistance. The 10C7 antibody specifically binds to GPR56 on the surface of cancer cells, facilitating the internalization of the ADC. Once inside the cell, the duocarmycin payload is released, acting as a potent DNA-alkylating agent that induces DNA damage and subsequent apoptosis. Preclinical studies in CRC cell lines, patient-derived organoids, and xenograft models have demonstrated significant antitumor efficacy and selective cytotoxicity, providing a rationale for targeting GPR56 in MSS colorectal cancer patients.

Other names

10C7-duocarmycinanti-GPR56 ADCanti-GPR-56 ADCanti-GPR 56 ADCGPR56-ADCGPR-56-ADCGPR 56-ADC