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10R-siRNA

Development stage: Preclinical
Lead developer: Carnegie Mellon University Qatar
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Peptides, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Intravenous

Overview

10R-siRNA is a preclinical peptide-siRNA nanocomplex designed for the tumor-specific targeting and silencing of lactate dehydrogenase C (LDHC). It consists of a cell-penetrating 10R polyarginine peptide electrostatically complexed with an siRNA targeting LDHC. LDHC is highly expressed in certain tumors, such as triple-negative breast cancer (TNBC), where it acts as a key regulator of the DNA damage response and tumor mitotic fidelity. By delivering the siRNA into tumor cells, 10R-siRNA downregulates LDHC expression, reducing tumor cell clonogenicity and enhancing sensitivity to DNA-damaging therapeutics like olaparib.

Other names: 10R-siLDHC10R-siRNA complex

Targets

αVβ3 (Integrin αVβ3)Lactate dehydrogenase C (LDHC) mRNA

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