11-dehydrosinulariolide

11-Dehydrosinulariolide is a bioactive cembranolide diterpene isolated from the cultured soft coral *Sinularia flexibilis*. It has demonstrated significant anti-tumor activity in preclinical models, particularly against small cell lung cancer (SCLC), oral squamous cell carcinoma, and melanoma. The compound exerts its effects by inducing G2/M phase cell cycle arrest and triggering apoptosis through multiple pathways. Key mechanisms include the activation of the DNA damage response via the ATM/Chk2 pathway, upregulation of p53 and Bax, and activation of caspases-3 and -7. Additionally, it promotes the accumulation of the tumor suppressor PTEN, which subsequently inhibits the Akt signaling pathway, further suppressing tumor cell proliferation and survival.

Other names

11-dehydrosinulariolide